DNA condensation. Genomic DNAs are extremely long molecules. Brand new cuatro.dos million legs pairs of your own Age. coli chromosome extend to one.4 millimeters. In the physical assistance, a lot of time DNA particles have to be compacted to fit with the tiny areas in to the a cell, nucleus otherwise malware particle. The newest productive traps to tight packing from DNA happen from decreased configurational entropy, bending the latest stiff twice helix, and you can intermolecular (otherwise inter-segment) electrostatic repulsion of your own negatively recharged DNA phosphate organizations.