I declaration an effective 52-year-dated lady which have a great six-seasons reputation of dermatomyositis sine myositis, who developed down extremity edema and you can proteinuria. Pathological examination of renal biopsy presented membranoproliferative glomerulonephritis. She gotten steroid, cyclophosphamide, and mycophenolate mofetil. Along side nine in order to 10 months after the beginning of medication, the fresh proteinuria try enhanced.
Dermatomyositis (DM) are a keen autoimmune problem you to definitely characterized by engagement of proximal musculature and body. Rarely DM gift ideas with feature cutaneous signs in place of strength wedding, the new so named dermatomyositis sine myositis . Kidney engagement was uncommon into the dermatomyositis particularly in sine myositis variant from DM versus almost every other autoimmune conditions including SLE, endemic scleroderma, and tiny polyarteritis nodosa . We report someone who developed membranoproliferative glomerulonephritis (MPGN) six ages following the analysis out-of dermatomyositrs sine myositis.
dos. Circumstances Statement
A 52-year-dated lady is actually acknowledge to the health having chronic coughing, exertional dyspnea, and you can edema of all the way down extremities into the . Dermatomyositis sine myositis was diagnosed on her behalf with regular Gottron’s indication, heliotrope rash, periods off mechanic’s hands, and nail flex Las Vegas singles capillary transform rather than muscle tissue tiredness regarding six years back. At the time, serologic examination particularly ANA and anti-dsDNA have been bad, and C3, C4, and you can CH50 accounts was regular.